"In 1942 Dr Harry Klinefelter and his co-workers published a study about nine men who had enlarged breasts, sparse facial & body hair & small, firm, infertile testes. By the late 1950s other researchers discovered that men with Klinefelter's Syndrome had an extra sex chromosome giving 47XXY instead of the more usual 46XY. Based on studies in the US in the 1970s it is clear that Klinefelter Syndrome is one of the commonest genetic abnormalities known; 1 in 500 to 1 in 1000 live births."
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